Pipeline

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Pioneering biology to restore immune recognition

Pheast Therapeutics is advancing a robust discovery pipeline of targeted therapeutics to redefine cancer treatment.

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Program	Description	Indication	Discovery
PHST001	Anti-CD24 macrophage checkpoint inhibitor	Oncology	Current Phase: Phase 1
PHST677	Bispecific ADC targeting CDH1 and Nectin4	Oncology	Current Phase: IND Enabling
PHST002	Undisclosed	Oncology	Current Phase: IND Enabling
PHST004	Undisclosed	Oncology	Current Phase: Discovery

For information about early access to our investigational therapies, please review our Compassionate Use / Expanded Access policy.

Anti-CD24: A Next Generation Cancer Therapy

PHST001 is an anti-CD24 macrophage checkpoint inhibitor designed to overcome immune suppression in the tumor microenvironment and restore immune recognition to attack cancer. CD24, an immune receptor which was discovered by several Pheast co-founders, acts as a “don’t eat me” signal for cancer cells, shielding them from immune attack. By potently blocking the CD24-Siglec10 interaction, PHST001 enables macrophages to phagocytose cancer cells, initiating a powerful immune response.

Pheast is conducting a Phase 1 clinical trial of PHST001 in patients with advanced solid tumors (ClinicalTrials.gov Identifier: NCT06840886). The study aims to evaluate safety, pharmacokinetics, and early signs of anti-tumor activity, with the goal of establishing a recommended Phase 2 dose.

Phase 1 Clinical Trial

‍We are actively advancing our Phase 1 clinical trial and welcome inquiries from investigators, partners, and other interested parties. For more information about the study, please contact us.

Potential for Broad Efficacy across CD24+ Cancers:

CD24 is over expressed on many cancers, including but not limited to ovarian cancer, triple negative breast cancer, colorectal cancer, cholangiocarcinoma

Re-shaping the Tumor Microenvironment:

PHST001 may improve the anti-cancer response by other immune cells.

Engineering Excellence:

PHST001 was uniquely designed to bind all glyco-variants of CD24, ensuring robust activity across tumor types. With PHST001, we are targeting hard to treat cancers, with the potential to make a therapeutic impact in indications where existing immunotherapies have had limited success.

Potent Preclinical Results:

PHST001 demonstrates strong monotherapy efficacy in solid tumor models compared to other macrophage checkpoint inhibitors.

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Why CD24

Pheast’s initial focus on CD24 is based on the wealth of biological evidence, including human and cancer genetics, that highlight its important role in immune suppression in the tumor microenvironment. It is highly expressed in multiple cancer indications where other macrophage inhibitors have yet to demonstrate a clinical impact.

In some cancer types, CD24 is also a strong indicator of prognosis as patients with tumors that highly express CD24 have significantly lower survival rates than those with tumors expressing little CD24. In addition, CD24 presents advantages over some previously tested macrophage checkpoint targets. In particular, CD24 is not expressed on some sensitive hematopoietic cell types, such as red blood cells and platelets, which have posed safety challenges for other macrophage checkpoint targets.

Our Pipeline: The Next Frontier of Cancer Treatment

CD24 is just one of a multitude of “don’t eat me” signals, and our experiments make it clear that some cancers are protected by multiple barriers to macrophage activation. We have expanded the same genetic technologies and molecular methods that were used to identify CD24 and have identified novel macrophage checkpoint targets. In selecting our next development programs, we have engineered antibodies to target macrophage checkpoints and tumor-specific antigens, along with increasing therapeutic efficiency by adding cytotoxic payloads.

Read the Nature paper

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Our discovery platform is unlocking new frontiers in oncology, focusing on:

Identifying novel immune regulators using cutting-edge screening technologies
Addressing challenging indications in oncology and immune disorders
Advancing complementary approaches to maximize therapeutic impact

Barkal, et al. 2019

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